Amniotic Membrane as Biological Scaffold
The science of stem cells and their possible applications in the field of regenerative medicines has been a subject of great optimism for treating various debilitating diseases. Since the first hit and trial in 1960s, there has been a speedy up-gradation of technology to detach stem cells from various sources at different levels of potency. In this sense, these are the cardinal players in the pyramid of human development; with an inherent competence to give rise to cells of different tissue-specific functions and hence are practically present in each organ as maintenance support in normal wear and tear of the body.
Stem cells isolated from the extraembryonic tissues are the most attractive sources of all, being easily available, ethically exempted, functionally safe, and blessed with the same efficiency as embryonic stem cells. The effective applications of these stem cells in spinal cord injuries, neurodegenerative disorders, blood disorders, and autoimmune disorders have been endorsed by various scientists, regulatory bodies, and clinical trials. With the technological advancements, it is now possible to bank these stem cells as a total health guarantee of the complete family. Thus, many expectant parents are now routinely storing their baby’s stem cells; to be available for use in existing and future medical treatments.
Among various extra-embryonic tissue sources available, cord blood and cord tissue are widely collected and stored as medical insurance of the entire family. However, amniotic membrane derived from the human placental tissue is still overlooked, in spite of having a variety of uses in a broad range of clinical applications in tissue reconstruction. It is a multi-layered tissue with epithelial cells, basement membrane and avascular connective tissue matrix.
With our team of proficient scientists, we have explored for the first time in India; an acquisition of technological excellence in collecting, processing and storage of autologous amniotic membranes as organic scaffolds with an intention to use them as a wound covering for surgical sites, birthmarks/scars and tissue defects as in cases of burns and/or severe injuries.
It can thus be used as the biological foundation for faster regeneration of tissue such as skin that can enhance healing but still maintain the natural, structural and functional properties of the tissue.
Amniotic Tissue Allograft: – Features and Benefits
- The graft can be a good source of naturally occurring active growth factors such as fibronectin, integrins, and laminin; helping in resident stem cells stimulation, cellular proliferation and faster differentiation into desired tissue specific cells.
- It is made up of collagen and fibrous proteins that can be used as a good structural support for better cellular adherence, promoting cellular migration and faster reconstruction of the tissue.
- It has been confirmed that these grafts have immune privileged and immune modulatory effects, thus minimizing the risk of other opportunistic infections.
- The graft supports in reduction of inflammation, fibrous tissue growth and potential scar tissue formation, thus have many applications in wound healing, eye disorders and cosmetic procedures.
The Process: – This proprietary procedure of storing amniotic membrane has been developed by taking into account regulatory issues such as safety, efficacy, sterility and feasibility of separating it gently from other placental tissues. The process involves stringent steps such as cleaning, sterilization, separation and decellularization of the membrane in way that the key elements associated with the healing are preserved with an intact extracellular matrix; before storage. The result is the clear, durable graft that expedites the patient’s recovery by reducing inflammation, faster healing, suppressing pain associated with the injury and achieving a superior cosmetic outcome. We are taking care not to add any extra unnecessary chemicals during the process that can promote unwanted effects.
Thus, along with other extra-embryonic tissues such as cord blood, cord tissue, etc. storage of amniotic membranes can be an added advantage to deliver clinically effective and minimally manipulated scaffolds for managing chronic wounds, cosmetic issues and eye problems.